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KMID : 1094020180350060311
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Journal of Veterinary Clinics
2018 Volume.35 No. 6 p.311 ~ p.314
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Corneal Squamous Cell Carcinoma Presumed to Arise from Corneal Fibrosis in a Shih-Tzu Dog
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Kim Eun-Jik
Park Young-Woo
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Abstract
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Squamous cell carcinoma (SCC) is a form of neoplasm that origins from the epithelial surface of manyorgans. Ocular occurrence in small animals is rare, especially in the central cornea without the involvement of limbusor conjunctiva. In the current case, a 10-year-old, spayed female Shih-Tzu was presented with a central corneal mass. Through an ophthalmic examination the sign of corneal scarring around the mass was found. Pink fleshy lesion thatprotruded outward was removed through superficial keratectomy. The mass with the size of 8.5 × 6.5 millimeter washistopathologically diagnosed as corneal SCC infiltrating not only the epithelium, but also the superficial corneal stromawith surrounding superficial lymphoplasmacytic and neutrophilic chronic keratitis. Also, the adjacent, non-affectedcorneal epithelium was markedly hyperplastic and keratinized; the adjacent stroma was moderately vascularized andfibrotic. The pulse-dose therapy using 1% topical 5-flourouracil were applied for five cycles. The tumor has not recurredthrough nine months of follow-up time.
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KEYWORD
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5-fluorouracil, corneal scarring, corneal squamous cell carcinoma, Shih-Tzu
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